“To acheive great things, two things are needed: a plan and not quite enough time ”

- Leonard Bernstein -

PROJECTS

How does isoplastic variation in body size impact key aspects of cellular physiology?

 C. inopinata and C. elegans have the same number of cells, but C. inopinata is nearly twice as long due to larger cell size. What could be the advantage(s) of having larger cells? Work by Dr. Stephen Kinsey shows that larger cells use energy more efficiently. A new collaboration between the Fausett and Kinsey labs aims to study the cellular physiology of these and other nematodes to better understand the impact of cell size on energy processing.

Background image from article by Vicky Hunt

Quantitative Trait Loci Mapping of Variation in the

Germ Stem Cell Niche

C. elegans' germ stem cell niche is a fascinating and elegant system that responds sensitively to the worm's environment, linking sensory and metabolic inputs directly with  reproductive output. This project aims to map natural phenotypic variation in the size/activity of the germ stem cell niche to discover causal genetic variants. This work has been done in collaboration with Dr. Christian Braendle.

Gene x Environment Interactions Through Metabolomics

The metabolome is a detailed and quantitative picture of whole-organism phenotype. Our goal is to develop approaches and techniques to study the metabolome of C. elegans and investigate the influence of both genotype and the environment on the metabolome. 

PUBLICATIONS

University of North Carolina Wilmington

Center for Marine Science
5600 Marvin K. Moss Lane, Wilmington, NC, 28409-5928

fausetts@uncw.edu

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